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M94A2664.TXT
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1994-10-25
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Document 2664
DOCN M94A2664
TI Testing pooled sera for HIV antibodies.
DT 9412
AU Torimiro JN; Ashu FA; Lobe VE; Ndumbe PM; Center for the Study and
Control of Communicable Diseases,; F.M.B.S., University of Yaounde I,
Cameroon.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):252 (abstract no. PB0436). Unique
Identifier : AIDSLINE ICA10/94369911
AB OBJECTIVES: To assess whether the testing of pooled sera is technically
feasible, cost-effective and accurate for estimating seroprevalence in
large population surveys. METHODS: 760 sera of known HIV reactivity were
made into 152 pools by mixing 100 microliters of each constituent
sample, (1 in 5) and 76 pools by mixing 100 microliters of 2 pools of 5
(1 in 10). Testing was with 3 ELISAs (Vironostika, Enzygnost, Elavia)
and 2 rapid tests (PATH Dipstick and Clonatec). RESULTS: TABULAR DATA,
SEE ABSTRACT VOLUME. DISCUSSION AND CONCLUSIONS: Pooling at 1 in 5 is
more sensitive and specific than for 1 in 10 pools. An overall gain in
time (about 48%) and cost savings are obtained with such schemes.
Testing pooled sera ought to be widely used in seroepidemiologic studies
in developing countries.
DE AIDS Serodiagnosis/*METHODS *Blood Banks Cameroon/EPIDEMIOLOGY
Comparative Study Enzyme-Linked Immunosorbent Assay/*METHODS Human
HIV Antibodies/*BLOOD HIV
Seropositivity/DIAGNOSIS/*EPIDEMIOLOGY/IMMUNOLOGY/ TRANSMISSION *HIV
Seroprevalence *Population Surveillance Predictive Value of Tests
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).